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mntD [2017-10-19 17:44:30]
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mntD [2017-10-19 17:44:30]

manganese ABC transporter (permease)
locus
BSU30740
pI
6.31
mw
30.91 kDa
protein length
295 aa Sequence Blast
gene length
885 bp Sequence Blast
function
manganese uptake
product
manganese ABC transporter (permease)
essential
no
synonyms
ytgD
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.6|Uptake of ions]
  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.2|Manganese]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    3,142,077 → 3,142,964

    The protein

    Protein family

  • ABC-3 integral membrane protein family (according to Swiss-Prot)

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|3C40A6E42A669E77ADBF5FFF334061C51F76A4F9|mntA]-[gene|7821C82C6C30079F713B84F1E4D654E07CE5072E|mntB]-[gene|1B7C4AD6CD0632051A0E8CA57034872D13FF67F9|mntC]-[gene|F7DA077FE47DBB409BE2B1D9F12A9D719C246166|mntD]
    description
    [Pubmed|10760146]

    regulatory mechanism

  • [protein|FF34DC303E8A7C9FAA205A6C2924961963B14EB1|MntR]: repression, [Pubmed|12950915], in [regulon|FF34DC303E8A7C9FAA205A6C2924961963B14EB1|MntR regulon]

    • regulation

  • repressed at high Mn(II) concentrations ([protein|search|MntR]) [Pubmed|12950915]

    • additional information

  • A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]
    • view in new tab

    Biological materials

    Mutant

  • MGNA-A288 (ytgD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/288 NBRP B. subtilis, Japan]
  • BKE30740 (Δ[gene|F7DA077FE47DBB409BE2B1D9F12A9D719C246166|mntD]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE30740 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CTTCAAAACTCATTTGCGAT, downstream forward: _UP4_GGCTGATGCAGCTCTTTCTT
  • BKK30740 (Δ[gene|F7DA077FE47DBB409BE2B1D9F12A9D719C246166|mntD]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK30740 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CTTCAAAACTCATTTGCGAT, downstream forward: _UP4_GGCTGATGCAGCTCTTTCTT

    • Labs working on this gene/protein

  • [SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

    • References

  • 10760146,10092453,12950915,10760146,10760146